Updated on 2023/04/25

写真a

 
Ken-ichi Nihei
 
Organization
School of Agriculture Department of Applied Biological Chemistry Professor
Institute for Promotion of Research Center for Bioscience Research and Education Professor
Graduate School of Regional Development and Creativity Division of Engineering and Agriculture (Master's Course) Graduate Program in Agricultural Biological Chemistry Professor
United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology Applied Life Science (Doctor's Course) Professor
Title
Professor

Degree

  • 博士(農学) ( 1998.3   岩手大学 )

Research Interests

  • Natural Products Chemistry

  • Inhibitor Design

  • Organic Synthesis

Research Areas

  • Life Science / Bioorganic chemistry

  • Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules

 

Papers

  • Total synthesis of (-)-ribesin B and its structural revision Reviewed

    Horio K, Nihei K

    Tetrahedron Lett.   114   154285   2023

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  • Chemical synthesis and tyrosinase inhibitory activity of resorcinol alkyl glucosides, hydroxyalkyl resorcinols, and alkyl resorcinols Reviewed

    Ishioka W, Nihei K

    J. Mol. Struct.   1268   133668   2022

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  • Synthesis, structural revision, and tyrosinase inhibitory activity of proposed phloretin-4-O-β-D-glucopyranoside from Homalium stenophyllum Reviewed

    Shimakage R, Nihei K

    Nat. Prod. Res.   36   1803 - 1811   2022

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  • Intracellular oxidation of methyl p-coumarate is involved in anti-melanogenic and cytotoxic activities against melanoma cells Reviewed

    Satooka H, Nihei K, Kubo I

    Phytochem. Lett.   50   89 - 94   2022

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  • Isolation and characterization of FMRFamide-like peptides in the venoms of solitary sphecid wasps Reviewed

    Nihei K, Peigneur S, Tytgat J, Lange AB, Konno K

    Peptides   142   170575   2021

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  • Comprehensive analysis and biological characterization of venom components from solitary scoliid wasp Campsomeriella annulata annulate Reviewed

    Alberto-Silva C, Portaro FCV, Kodama RT, Pantaleão HQ, Inagaki H, Nihei K, Konno K

    Toxins   13   885   2021

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  • Novel neuroprotective peptides in the venom of the solitary scoliid wasp Scolia decorata ventralis Reviewed

    Alberto-Silva C, Portaro FCV, Kodama RT, Pantaleão HQ, Rangel M, Nihei K, Konno K

    J. Venom Anim. Toxins incl. Trop. Dis.   27   e20200171   2021

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  • Comprehensive analysis of peptides and low molecular weight components of the giant ant Dinoponera quadriceps venom Reviewed

    Rádis-Baptista G, Dodou HV, Prieto-da-Silva ÁRB, Zaharenko AJ, Kazuma K, Nihei K, Inagaki H, Mori-Yasumoto K, Konno K

    Biol. Chem.   401   945 - 954   2020

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  • Tyrosinase inhibition by 4-substituted benzaldehydes with electron-withdrawing groups Reviewed

    Nihei K, Kubo I

    Appl. Biochem. Biotechnol.   191   1711 - 1716   2020

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  • Systematic approach to the chemical synthesis of arabidopyrones, the unique α-pyrones of Arabidopsis metabolites Reviewed

    Matsunoto T, Harima S, Weng J, Nihei K

    Synth. Commun.   50   2981 - 2987   2020

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  • Molecular design of potent, hydrophilic tyrosinase inhibitors based on the natural dihydrooxyresveratrol skeleton Reviewed

    Tanaka Y, Suzuki M, Kodachi Y, Nihei K

    Carbohydr. Res.   472   42 - 49   2019

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  • Benzonitriles as tyrosinase inhibitors with hyperbolic inhibition manner Reviewed

    Nihei K, Kubo I

    Int. J. Biol. Macromol.   133   929 - 932   2019

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  • Total synthesis of apios isoflavones and investigation of their tyrosinase inhibitory activity Reviewed

    Asebi N, Nihei K

    Tetrahedron   75   130589   2019

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  • Extraction of strawberry leaves with supercritical carbon dioxide and entrainers: Antioxidant capacity, total phenolic content, and inhibitory effect on uric acid production of the extract Reviewed

    Sato T, Ikeya Y, Adachi S, Yagasaki K, Nihei K, Itoh N

    Food Bioprod. Process.   117   160 - 169   2019

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  • Resorcinol alkyl glucosides as potent tyrosinase inhibitors Reviewed

    Ishioka W, Oonuki S, Iwadate T, Nihei K

    Bioorg. Med. Chem. Lett.   29   313 - 316   2019

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  • Chemical synthesis and tyrosinase-inhibitory activity of isotachioside and its related glycosides Reviewed

    Matsumoto T, Nakajima T, Iwadate T, Nihei K

    Carbohydr. Res.   465   22 - 28   2018

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  • Effect of temperature and pressure on the extraction of strawberry receptacles with a mixture of supercritical carbon dioxide and entrainers Reviewed

    Sato T, Fukuda F, Nihei K, Itoh N

    J. Supercrit. Fluids   130   23 - 29   2017

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  • Substituent effect of benzaldehydes on tyrosinase inhibition Reviewed

    Nihei K, Kubo I

    Plant Physiol. Biochem.   112   278 - 282   2017

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  • Anti-hyperuricemic effect of taxifolin in cultured hepatocytes and model mice Reviewed

    Adachi S, Nihei K, Ishihara Y, Yoshizawa F, Yagasaki K

    Cytotechnology   69   329 - 336   2017

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  • Chemical synthesis, redox transformation, and identification of sonnerphenolic C, an antioxidant in Acer nikoense Reviewed

    Iwadate T, Nihei K

    Bioorg. Med. Chem. Lett.   27   1799 - 1802   2017

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  • Peptidomic analysis of the venom of the solitary bee Xylocopa appendiculata circumvolans Reviewed

    Kazuma K, Ando K, Nihei K, Wang X, Rangel M, Franzolin MR, Mori-Yasumoto K, Sekita S, Kadowaki M, Satake M, Konno K

    J. Venom Anim. Toxins incl. Trop. Dis.   23   40   2017

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  • Dihydroresveratrol cellobioside and xylobioside as effective melanogenesis activators Reviewed

    Oode C, Shimada W, Yokota M, Yamada Y, Nihei K

    Carbohydr. Res.   436   45 - 49   2016

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  • Peptide toxins in solitary wasp venoms Reviewed

    Konno K, Kazuma K, Nihei K

    Toxins   8   114   2016

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  • Cloning and functional analysis of three chalcone synthases from the flowers of safflowers Carthamus tinctorius Reviewed

    Shinozaki J, Kenmoku H, Nihei K, Masuda K, Noji M, Konno K, Asakawa Y, Kazuma K

    Nat. Prod. Commun.   11   787 - 790   2016

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  • Rhododendrol glycosides as stereospecific tyrosinase inhibitors Reviewed

    Iwadate T, Nihei K

    Bioorg. Med. Chem.   23   6650 - 6658   2015

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  • Inhibitory effects of cardols and related compounds on superoxide anion generation by xanthine oxidase Reviewed

    Masuoka N, Nihei K, Maeta A, Yamagiwa Y, Kubo I

    Food Chem.   166   270 - 274   2015

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  • Stereochemical investigation and total synthesis of inuloidin, a biologically active sesquiterpenoid from Heterotheca inuloides Reviewed

    Kamatani J, Iwadate T, Tajima R, Kimoto H, Yamada Y, Masuoka N, Kubo I, Nihei K

    Tetrahedron   70   3141 - 3145   2014

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  • Synthesis of dihydroresveratrol glycosides and their effects on B16F0 melanoma cells Reviewed

    Oode C, Shimada W, Izutsu Y, Yokota M, Iwadate T, Nihei K

    Eur. J. Med. Chem.   87   862 - 867   2014

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  • Chemical synthesis and tyrosinase inhibitory activity of rhododendrol glycosides Reviewed

    Iwadate T, Kashiwakura Y, Masuoka N, Yamada Y, Nihei K

    Bioorg. Med. Chem. Lett.   24   122 - 125   2014

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  • Identification of nitric oxide generation-stimulative principle in Scutellariae radix Reviewed

    Chen Z, Nihei K, Tanaka H, Uda Y, Kabuyama Y

    Biosci. Biotechnol. Biochem.   77   657 - 659   2013

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  • Absolute stereochemistry of altersolanol A and alterporriols. Reviewed

    Kanamaru S, Honma M, Murakami T, Tsushima T, Kudo S, Tanaka K, Nihei K, Nehira T, Hashimoto M

    Chirality   24   137 - 146   2012

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  • ニワトリ角膜におけるコレステロールエステルとアポリポタンパク質A-I Reviewed

    谷優里,塚原直樹,蕪山由己人,二瓶賢一,杉田昭栄

    日本家禽学会誌   49   J1 - J6   2012

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  • Novel isoflavone diglycoside in groundnut (Apios americana Medik) Reviewed

    Nara K, Nihei K, Ogasawara Y, Koga H, Kato Y

    Food Chem.   124   703 - 710   2011

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  • High levels of apolipoproteins found in the soluble fraction of avian cornea Reviewed

    Tsukahara N, Tani Y, Nihei K, Kabuyama Y, Sugita S

    Exp. Eye Res.   92   432 - 435   2011

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  • Chemical and biological characterization of four new linear cationic cytolytic peptides from the venoms of two solitary eumenine wasps Reviewed

    Rangel M, Cabrera MPS, Kazuma K, Ando K, Wang X, Kato M, Nihei K, Hirata IY, Cross TJ, Garcia AN, Faquim-Mauro EL, Franzolin MR, Fuchino H, et al

    Toxicon   47   1081 - 1092   2011

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  • Synthesis and evaluation of bibenzyl glycosides as potent tyrosinase inhibitors Reviewed

    Tajima R, Oozeki H, Muraoka S, Tanaka S, Motegi Y, Nihei K

    Eur. J. Med. Chem.   46   1374 - 1381   2011

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  • Genetic replacement of tesB with PTE1 affects chain-length proportions of 3-hydroxyalkanoic acids produced through β-oxidation of oleic acid in Escherichia coli Reviewed

    Seto Y, Kang J, Ming L, Habu N, Nihei K, Ueda S, Maeda I

    J. Biosci. Bioeng.   110   392 - 396   2010

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  • Four analogues of spiroleptosphol isolated from Leptosphaeria doliolum Reviewed

    Murakami T, Tsushima T, Takada N, Tanaka K, Nihei K, Miura T, Hashimoto M

    Bioorg. Med. Chem.   17   492 - 495   2009

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  • Sweet and bitter constituents of Wilbrandia species Reviewed

    Ochi M, Moriyama K, Ohmae K, Fukuyama Y, Nihei K, Kubo I

    Food Chem.   115   61 - 65   2009

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  • Absorption of hydroxyproline-containing peptides in vascularly perfused rat small intestine in situ Reviewed

    Liu C, Sugita K, Nihei K, Yoneyama K, Tanaka H

    Biosci. Biotechnol. Biochem.   73   1741 - 1747   2009

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  • Antimicrobial activity of anethole and related compounds from aniseed Reviewed

    Kubo I, Fujita K, Nihei K

    J. Sci. Food Agric.   88   242 - 247   2008

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  • Molecular design of potent tyrosinase inhibitors having the bibenzyl skeleton Reviewed

    Oozeki H, Tajima R, Nihei K

    Bioorg. Med. Chem. Lett.   18   5252 - 5254   2008

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  • Design and evaluation of anacardic acid derivatives as anti-cavity agents Reviewed

    Green IR, Tocoli FE, Lee SH, Nihei K, Kubo I

    Eur. J. Med. Chem.   43   1315 - 1320   2008

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  • Insect growth inhibitory activity and cytotoxicity of tannic acid from Gallae rhois Reviewed

    Kubo I, Hori I, Nihei K, Satooka H, Céspedes CL, Calderón JS

    Biopestic. Int.   4   6 - 14   2008

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  • Effects of quercetin on mushroom tyrosinase and B16-F10 melanoma cells Reviewed

    Kubo I, Nitoda T, Nihei K

    Molecules   12   1045 - 1056   2007

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  • Molecular design of anti-MRSA agents based on the anacardic acid scaffold Reviewed

    Green IR, Tocoli FE, Lee SH, Nihei K, Kubo I

    Bioorg. Med. Chem.   15   6236 - 6241   2007

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  • Manicoba, a quercetin-rich Amazonian dish Reviewed

    Kubo I, Masuoka N, Nihei K, Burgheim B

    J. Food Compos. Anal.   19   579 - 588   2006

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  • An RNA polymerase inhibitor, cyclothiazomycin B1, and its isomer Reviewed

    Hashimoto M, Murakami T, Funahashi K, Tokunaga T, Nihei K, Okuno T, Kimura T, Naoki H, Himeno H

    Bioorg. Med. Chem.   14   8259 - 8270   2006

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  • Musidunin and musiduol, insect antifeedants from Croton jatrophoides Reviewed

    Nihei K, Asaka Y, Mine Y, Yamada Y, Iigo M, Yanagisawa T, Kubo I

    J. Nat. Prod.   69   975 - 977   2006

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  • An efficient and versatile synthesis of all structural types of acylpolyamine spider toxins Reviewed

    Nihei K, Kato MJ, Yamane T, Konno K

    Tetrahedron   69   8335 - 8350   2006

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  • Xanthine oxidase inhibitory activity of alkyl gallates Reviewed

    Masuoka N, Nihei K, Kubo I

    Mol. Nutr. Food Res.   50   725 - 731   2006

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  • Biological activities of 2α-substituted analogues of 1α,25-dihydroxyvitamin D3 in transcriptional regulation and human promyelocytic leukemia (HL-60) cell proliferation and differentiation Reviewed

    Takahashi E, Nakagawa K, Suhara Y, Kittaka A, Nihei K, Konno K, Takayama H, Ozono K, Okano T

    Biol. Pharm. Bull.   29   2246 - 2250   2006

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  • Enantioselective synthesis of four isomers of 3-hydroxy-4-methyltetradecanoic acid, the constituent of antifungal cyclodepsipeptides W493 A and B Reviewed

    Nihei K, Hashimoto K, Miyairi K, Okuno T

    Biosci. Biotechnol. Biochem.   69   231 - 234   2005

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  • The antiepileptic activity of JSTX-3 is mediated by N-methyl-D-aspartate receptors in human hippocampal neurons Reviewed

    Salamoni SD, Costa JC, Palma MS, Konno K, Nihei K, Neto AEP, Venturin GT, Travares AA, Abreu DS, Breda RV

    NeuroReport   16   1869 - 1873   2005

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  • Pachyelasides A-D, novel molluscicidal triterpene saponins from Pachyelasma tessmannii Reviewed

    Nihei K, Ying BP, Murakami H, Matsuda N, Hashimoto M, Kubo I

    J. Agric. Food Chem.   53   608 - 613   2005

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  • Insect antifeedants from Croton jatrophoides: Structures of zumketol, zumsenin, and zumsenol Reviewed

    Nihei K, Asaka Y, Mine Y, Kubo I

    J. Nat. Prod.   68   244 - 247   2005

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  • Antiepileptic effect of acylpolyaminetoxin JSTX-3 on rat hippocampal CA1 neurons in vitro Reviewed

    Salamoni SD, Costa JC, Palma MS, Konno K, Nihei K, Travaras AA, Abreu DS, Venturin GT, Cunha FB, Oliveira RM, Breda RV

    Brain Res.   1048   170 - 176   2005

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▼display all

MISC

  • メグスリノキと化学合成 Reviewed

    二瓶賢一,岩舘丈央

    化学と生物   58 ( 10 )   555 - 561   2020

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Class

  • 有機化学Ⅱ  A000490

    2022  ( University )

  • 有機化学Ⅰ  A000045

    2022  ( University )

  • 天然物化学  A000525

    2022  ( University )

  • 生理活性物質化学  B100327

    2022  ( Graduate School )