研究推進機構 バイオサイエンス教育研究センター 教授
地域創生科学研究科 博士前期課程 工農総合科学専攻 農芸化学プログラム 教授
東京農工大学大学院 連合農学研究科 博士後期課程 応用生命科学専攻 教授
2024/10/24 更新
博士(農学) ( 1998年3月 岩手大学 )
天然物化学
阻害剤開発
有機合成
ライフサイエンス / 生物有機化学
ナノテク・材料 / 生物分子化学
A natural diphenolic glucoside, sonnerphenolic C: Chemical synthesis, structural revision, redox transformation, and identification as an antioxidant 査読
Shimakage R, Iwadate T, Nihei K
Tetrahedron 158 134001 2024年
Total synthesis of nepodin and torachrysone glucosides: Evidence for naturally occurring L-glucosides 査読
Makita M, Nihei K
Tetrahedron Lett. 146 155191 2024年
Temporal dynamics of N-hydroxypipecolic acid and salicylic acid pathways in the disease response to powdery mildew in wheat 査読
Sato Y, Weng Y, Shimazaki T, Yoshida K, Nihei K, Okamoto M
Biochem. Biophys. Res. Commun. 734 150624 2024年
Scoliidines: Neuroprotective peptides in solitary scoliid wasp venoms 査読
Alberto-Silva C, Portaro FCV, Kodama RT, Gomes L, da Silva BR, da Cunha e Silva FA, Nihei K, Konno K
Toxins 16 446 2024年
“Fruiting liquid” of mushroom-forming fungi, a novel source of bioactive compounds – Fruiting-body inducer and HIF and Axl inhibitors 査読
Wu J, Uchida K, Yoshikawa A, Hashimoto M, Kondo M, Nihei K, Ishii M, ... Kawagishi H.
J. Agric. Food Chem. 71 13338 2023年
Total synthesis of (-)-ribesin B and its structural revision 査読
Horio K, Nihei K
Tetrahedron Lett. 114 154285 2023年
Chemical synthesis and tyrosinase inhibitory activity of resorcinol alkyl glucosides, hydroxyalkyl resorcinols, and alkyl resorcinols 査読
Ishioka W, Nihei K
J. Mol. Struct. 1268 133668 2022年
Intracellular oxidation of methyl p-coumarate is involved in anti-melanogenic and cytotoxic activities against melanoma cells 査読 国際共著
Satooka H, Nihei K, Kubo I
Phytochem. Lett. 50 89 - 94 2022年
Novel neuroprotective peptides in the venom of the solitary scoliid wasp Scolia decorata ventralis 査読
Alberto-Silva C, Portaro FCV, Kodama RT, Pantaleão HQ, Rangel M, Nihei K, Konno K
J. Venom Anim. Toxins incl. Trop. Dis. 27 e20200171 2021年
Comprehensive analysis and biological characterization of venom components from solitary scoliid wasp Campsomeriella annulata annulate 査読
Alberto-Silva C, Portaro FCV, Kodama RT, Pantaleão HQ, Inagaki H, Nihei K, Konno K
Toxins 13 885 2021年
Isolation and characterization of FMRFamide-like peptides in the venoms of solitary sphecid wasps 査読
Nihei K, Peigneur S, Tytgat J, Lange AB, Konno K
Peptides 142 170575 2021年
Synthesis, structural revision, and tyrosinase inhibitory activity of proposed phloretin-4-O-β-D-glucopyranoside from Homalium stenophyllum 査読
Shimakage R, Nihei K
Nat. Prod. Res. 36 1803 - 1811 2022年
Systematic approach to the chemical synthesis of arabidopyrones, the unique α-pyrones of Arabidopsis metabolites 査読
Matsunoto T, Harima S, Weng J, Nihei K
Synth. Commun. 50 2981 - 2987 2020年
Comprehensive analysis of peptides and low molecular weight components of the giant ant Dinoponera quadriceps venom 査読
Rádis-Baptista G, Dodou HV, Prieto-da-Silva ÁRB, Zaharenko AJ, Kazuma K, Nihei K, Inagaki H, Mori-Yasumoto K, Konno K
Biol. Chem. 401 945 - 954 2020年
Tyrosinase inhibition by 4-substituted benzaldehydes with electron-withdrawing groups 査読
Nihei K, Kubo I
Appl. Biochem. Biotechnol. 191 1711 - 1716 2020年
Molecular design of potent, hydrophilic tyrosinase inhibitors based on the natural dihydrooxyresveratrol skeleton 査読
Tanaka Y, Suzuki M, Kodachi Y, Nihei K
Carbohydr. Res. 472 42 - 49 2019年
Benzonitriles as tyrosinase inhibitors with hyperbolic inhibition manner 査読
Nihei K, Kubo I
Int. J. Biol. Macromol. 133 929 - 932 2019年
Total synthesis of apios isoflavones and investigation of their tyrosinase inhibitory activity 査読
Asebi N, Nihei K
Tetrahedron 75 130589 2019年
Extraction of strawberry leaves with supercritical carbon dioxide and entrainers: Antioxidant capacity, total phenolic content, and inhibitory effect on uric acid production of the extract 査読
Sato T, Ikeya Y, Adachi S, Yagasaki K, Nihei K, Itoh N
Food Bioprod. Process. 117 160 - 169 2019年
Resorcinol alkyl glucosides as potent tyrosinase inhibitors 査読
Ishioka W, Oonuki S, Iwadate T, Nihei K
Bioorg. Med. Chem. Lett. 29 313 - 316 2019年
Chemical synthesis and tyrosinase-inhibitory activity of isotachioside and its related glycosides 査読
Matsumoto T, Nakajima T, Iwadate T, Nihei K
Carbohydr. Res. 465 22 - 28 2018年
Effect of temperature and pressure on the extraction of strawberry receptacles with a mixture of supercritical carbon dioxide and entrainers 査読
Sato T, Fukuda F, Nihei K, Itoh N
J. Supercrit. Fluids 130 23 - 29 2017年
Substituent effect of benzaldehydes on tyrosinase inhibition 査読
Nihei K, Kubo I
Plant Physiol. Biochem. 112 278 - 282 2017年
Anti-hyperuricemic effect of taxifolin in cultured hepatocytes and model mice 査読
Adachi S, Nihei K, Ishihara Y, Yoshizawa F, Yagasaki K
Cytotechnology 69 329 - 336 2017年
Chemical synthesis, redox transformation, and identification of sonnerphenolic C, an antioxidant in Acer nikoense 査読
Iwadate T, Nihei K
Bioorg. Med. Chem. Lett. 27 1799 - 1802 2017年
Peptidomic analysis of the venom of the solitary bee Xylocopa appendiculata circumvolans 査読
Kazuma K, Ando K, Nihei K, Wang X, Rangel M, Franzolin MR, Mori-Yasumoto K, Sekita S, Kadowaki M, Satake M, Konno K
J. Venom Anim. Toxins incl. Trop. Dis. 23 40 2017年
Dihydroresveratrol cellobioside and xylobioside as effective melanogenesis activators 査読
Oode C, Shimada W, Yokota M, Yamada Y, Nihei K
Carbohydr. Res. 436 45 - 49 2016年
Peptide toxins in solitary wasp venoms 査読
Konno K, Kazuma K, Nihei K
Toxins 8 114 2016年
Cloning and functional analysis of three chalcone synthases from the flowers of safflowers Carthamus tinctorius 査読
Shinozaki J, Kenmoku H, Nihei K, Masuda K, Noji M, Konno K, Asakawa Y, Kazuma K
Nat. Prod. Commun. 11 787 - 790 2016年
Inhibitory effects of cardols and related compounds on superoxide anion generation by xanthine oxidase 査読
Masuoka N, Nihei K, Maeta A, Yamagiwa Y, Kubo I
Food Chem. 166 270 - 274 2015年
Rhododendrol glycosides as stereospecific tyrosinase inhibitors 査読
Iwadate T, Nihei K
Bioorg. Med. Chem. 23 6650 - 6658 2015年
Synthesis of dihydroresveratrol glycosides and their effects on B16F0 melanoma cells 査読
Oode C, Shimada W, Izutsu Y, Yokota M, Iwadate T, Nihei K
Eur. J. Med. Chem. 87 862 - 867 2014年
Chemical synthesis and tyrosinase inhibitory activity of rhododendrol glycosides 査読
Iwadate T, Kashiwakura Y, Masuoka N, Yamada Y, Nihei K
Bioorg. Med. Chem. Lett. 24 122 - 125 2014年
Stereochemical investigation and total synthesis of inuloidin, a biologically active sesquiterpenoid from Heterotheca inuloides 査読
Kamatani J, Iwadate T, Tajima R, Kimoto H, Yamada Y, Masuoka N, Kubo I, Nihei K
Tetrahedron 70 3141 - 3145 2014年
Identification of nitric oxide generation-stimulative principle in Scutellariae radix 査読
Chen Z, Nihei K, Tanaka H, Uda Y, Kabuyama Y
Biosci. Biotechnol. Biochem. 77 657 - 659 2013年
Absolute stereochemistry of altersolanol A and alterporriols. 査読
Kanamaru S, Honma M, Murakami T, Tsushima T, Kudo S, Tanaka K, Nihei K, Nehira T, Hashimoto M
Chirality 24 137 - 146 2012年
ニワトリ角膜におけるコレステロールエステルとアポリポタンパク質A-I 査読
谷優里,塚原直樹,蕪山由己人,二瓶賢一,杉田昭栄
日本家禽学会誌 49 J1 - J6 2012年
Synthesis and evaluation of bibenzyl glycosides as potent tyrosinase inhibitors 査読
Tajima R, Oozeki H, Muraoka S, Tanaka S, Motegi Y, Nihei K
Eur. J. Med. Chem. 46 1374 - 1381 2011年
Novel isoflavone diglycoside in groundnut (Apios americana Medik) 査読
Nara K, Nihei K, Ogasawara Y, Koga H, Kato Y
Food Chem. 124 703 - 710 2011年
High levels of apolipoproteins found in the soluble fraction of avian cornea 査読
Tsukahara N, Tani Y, Nihei K, Kabuyama Y, Sugita S
Exp. Eye Res. 92 432 - 435 2011年
Chemical and biological characterization of four new linear cationic cytolytic peptides from the venoms of two solitary eumenine wasps 査読
Rangel M, Cabrera MPS, Kazuma K, Ando K, Wang X, Kato M, Nihei K, Hirata IY, Cross TJ, Garcia AN, Faquim-Mauro EL, Franzolin MR, Fuchino H, et al
Toxicon 47 1081 - 1092 2011年
Genetic replacement of tesB with PTE1 affects chain-length proportions of 3-hydroxyalkanoic acids produced through β-oxidation of oleic acid in Escherichia coli 査読
Seto Y, Kang J, Ming L, Habu N, Nihei K, Ueda S, Maeda I
J. Biosci. Bioeng. 110 392 - 396 2010年
Four analogues of spiroleptosphol isolated from Leptosphaeria doliolum 査読
Murakami T, Tsushima T, Takada N, Tanaka K, Nihei K, Miura T, Hashimoto M
Bioorg. Med. Chem. 17 492 - 495 2009年
Sweet and bitter constituents of Wilbrandia species 査読
Ochi M, Moriyama K, Ohmae K, Fukuyama Y, Nihei K, Kubo I
Food Chem. 115 61 - 65 2009年
Absorption of hydroxyproline-containing peptides in vascularly perfused rat small intestine in situ 査読
Liu C, Sugita K, Nihei K, Yoneyama K, Tanaka H
Biosci. Biotechnol. Biochem. 73 1741 - 1747 2009年
Molecular design of potent tyrosinase inhibitors having the bibenzyl skeleton 査読
Oozeki H, Tajima R, Nihei K
Bioorg. Med. Chem. Lett. 18 5252 - 5254 2008年
Design and evaluation of anacardic acid derivatives as anti-cavity agents 査読
Green IR, Tocoli FE, Lee SH, Nihei K, Kubo I
Eur. J. Med. Chem. 43 1315 - 1320 2008年
Insect growth inhibitory activity and cytotoxicity of tannic acid from Gallae rhois 査読
Kubo I, Hori I, Nihei K, Satooka H, Céspedes CL, Calderón JS
Biopestic. Int. 4 6 - 14 2008年
Antimicrobial activity of anethole and related compounds from aniseed 査読
Kubo I, Fujita K, Nihei K
J. Sci. Food Agric. 88 242 - 247 2008年
Effects of quercetin on mushroom tyrosinase and B16-F10 melanoma cells 査読
Kubo I, Nitoda T, Nihei K
Molecules 12 1045 - 1056 2007年
Molecular design of anti-MRSA agents based on the anacardic acid scaffold 査読
Green IR, Tocoli FE, Lee SH, Nihei K, Kubo I
Bioorg. Med. Chem. 15 6236 - 6241 2007年
Manicoba, a quercetin-rich Amazonian dish 査読
Kubo I, Masuoka N, Nihei K, Burgheim B
J. Food Compos. Anal. 19 579 - 588 2006年
An RNA polymerase inhibitor, cyclothiazomycin B1, and its isomer 査読
Hashimoto M, Murakami T, Funahashi K, Tokunaga T, Nihei K, Okuno T, Kimura T, Naoki H, Himeno H
Bioorg. Med. Chem. 14 8259 - 8270 2006年
Musidunin and musiduol, insect antifeedants from Croton jatrophoides 査読
Nihei K, Asaka Y, Mine Y, Yamada Y, Iigo M, Yanagisawa T, Kubo I
J. Nat. Prod. 69 975 - 977 2006年
An efficient and versatile synthesis of all structural types of acylpolyamine spider toxins 査読
Nihei K, Kato MJ, Yamane T, Konno K
Tetrahedron 69 8335 - 8350 2006年
Xanthine oxidase inhibitory activity of alkyl gallates 査読
Masuoka N, Nihei K, Kubo I
Mol. Nutr. Food Res. 50 725 - 731 2006年
Biological activities of 2α-substituted analogues of 1α,25-dihydroxyvitamin D3 in transcriptional regulation and human promyelocytic leukemia (HL-60) cell proliferation and differentiation 査読
Takahashi E, Nakagawa K, Suhara Y, Kittaka A, Nihei K, Konno K, Takayama H, Ozono K, Okano T
Biol. Pharm. Bull. 29 2246 - 2250 2006年
The antiepileptic activity of JSTX-3 is mediated by N-methyl-D-aspartate receptors in human hippocampal neurons 査読
Salamoni SD, Costa JC, Palma MS, Konno K, Nihei K, Neto AEP, Venturin GT, Travares AA, Abreu DS, Breda RV
NeuroReport 16 1869 - 1873 2005年
Enantioselective synthesis of four isomers of 3-hydroxy-4-methyltetradecanoic acid, the constituent of antifungal cyclodepsipeptides W493 A and B 査読
Nihei K, Hashimoto K, Miyairi K, Okuno T
Biosci. Biotechnol. Biochem. 69 231 - 234 2005年
Pachyelasides A-D, novel molluscicidal triterpene saponins from Pachyelasma tessmannii 査読
Nihei K, Ying BP, Murakami H, Matsuda N, Hashimoto M, Kubo I
J. Agric. Food Chem. 53 608 - 613 2005年
Insect antifeedants from Croton jatrophoides: Structures of zumketol, zumsenin, and zumsenol 査読
Nihei K, Asaka Y, Mine Y, Kubo I
J. Nat. Prod. 68 244 - 247 2005年
Antiepileptic effect of acylpolyaminetoxin JSTX-3 on rat hippocampal CA1 neurons in vitro 査読
Salamoni SD, Costa JC, Palma MS, Konno K, Nihei K, Travaras AA, Abreu DS, Venturin GT, Cunha FB, Oliveira RM, Breda RV
Brain Res. 1048 170 - 176 2005年
メグスリノキと化学合成 査読
二瓶賢一,岩舘丈央
化学と生物 58 ( 10 ) 555 - 561 2020年
有機化学Ⅱ A000490
2022年度 ( 大学 )
天然物化学 A000525
2022年度 ( 大学 )
生理活性物質化学 B100327
2022年度 ( 大学院 )
有機化学Ⅰ A000045
2022年度 ( 大学 )