-
Analysis of the Stimulative Effect of Tryptophan on Hepatic Protein Synthesis in Rats
Reviewed
Obeng, K. A. Mochizuki, S. Koike, S. Toyoshima, Y. Sato, Y. Yoshizawa, F.
J Nutr Sci Vitaminol
68
(
4
)
312
-
319
2022.9
-
Essential Amino Acid Intake Is Required for Sustaining Serum Insulin-like Growth Factor-I Levels but Is Not Necessarily Needed for Body Growth
Reviewed
Nishi, H. Uchida, K. Saito, M. Yamanaka, D. Nagata, H. Tomoshige, H. Miyata, I. Ito, K. Toyoshima, Y. Takahashi, S. I. Hakuno, F. Takenaka, A.
Cells
11
(
9
)
1523
2022.5
-
Low-arginine and low-protein diets induce hepatic lipid accumulation through different mechanisms in growing rats
Reviewed
Otani, L., Nishi, H., Koyama, A., Akasaka, Y., Taguchi, Y., Toyoshima, Y., Yamanaka, D., Hakuno, F., Jia, H., Takahashi, S., Kato, H.
Nutr Metab (Lond)
17
60
2020.8
-
Disruption of insulin receptor substrate-2 impairs growth but not insulin function in rats
Reviewed
Toyoshima, Y., Nakamura, K., Tokita, R., Teramoto, N., Sugihara, H., Kato, H., Yamanouchi, K., Minami, S.
J Biol Chem
295
(
33
)
11914
-
11927
2020.7
-
Growth hormone increases regulator of calcineurin 1-4 (Rcan1-4) mRNA through c-JUN in rat liver
Reviewed
Nakata, T., Toyoshima, Y., Yagi, T., Katsumata, H., Tokita, R., Minami, S.
PLoS One
15
(
6
)
e0235270
2020.6
-
A translation repressor, 4E-BP1, regulates the triglyceride level in rat liver during protein deprivation
Reviewed
Toyoshima, Y., Yoshizawa, F., Tokita, R., Taguchi, Y., Takahashi, S., Kato, H., Minami, S.
Am J Physiol Endocrinol Metab
318
(
5
)
E636
-
E645
2020.5
-
Growth hormone activates X-box binding protein 1 in a sexually dimorphic manner through the extracellular signal-regulated protein kinase and CCAAT/enhancer-binding protein β pathway in rat liver
Reviewed
Nakata, T., Hirano, Y., Katsumata, H., Tokita, R., Yagi, T., Toyoshima, Y., Minami, S.
Endocr J
67
(
2
)
185
-
200
2020.2
-
Low-protein diet enhances adiponectin secretion in rats
Reviewed
Yagi, T., Toyoshima, Y., Tokita, R., Taguchi, Y., Okamoto, Y., Takahashi, S., Kato, H., Minami, S.
Biosci Biotechnol Biochem
83
(
9
)
1774
-
1781
2019.9
-
Importance of serum amino acid profile for induction of hepatic steatosis under protein malnutrition
Reviewed
Nishi, H., Yamanaka, D., Kamei, H., Goda, Y., Kumano, M., Toyoshima, Y., Takenaka, A., Matsuda, M., Nakabayashi, Y., Shioya, R., Kataoka, N., Hakuno,
Sci Rep
8
(
1
)
5461
2018.4
-
Branched-chain amino acid supplementation restores reduced insulinotropic activity of a low-protein diet through the vagus nerve in rats
Reviewed
Horiuchi, M., Takeda, T., Takahashi, H., Ozaki-Masuzawa, Y., Taguchi, Y., Toyoshima, Y., Otani, L., Kato, H., Sone-Yonezawa, M., Hakuno, F., Takahashi
Nutr Metab (Lond)
14
59
2017.9
-
Triglyceride synthesis in hepatocytes isolated from rats fed a low-protein diet is enhanced independently of upregulation of insulin signaling
Reviewed
Taguchi, Y., Toyoshima, Y., Tokita, R., Kato, H., Takahashi, S., Minami, S.
Biochem Biophys Res Commun
490
(
3
)
800
-
805
2017.8
-
Insulin injection restored increased insulin receptor substrate (IRS)-2 protein during short-term protein restriction but did not affect reduced insulin-like growth factor (IGF)-I mRNA or increased triglyceride accumulation in the liver of rats
Reviewed
Ozaki, Y., Takeda, T., Akanishi, N., Hakuno, F., Toyoshima, Y., Takahashi, S., Takenaka, A.
Biosci Biotechnol Biochem
78
(
1
)
130
-
138
2014.7
-
Tissue-specific effects of protein malnutrition on insulin signaling pathway and lipid accumulation in growing rats
Reviewed
61
(
5
)
499
-
512
2014.5
-
Dietary protein deprivation upregulates insulin signaling and inhibits gluconeogenesis in rat liver
Reviewed
Toyoshima, Y., Tokita, R., Ohne, Y., Hakuno, F., Noguchi, T., Minami, S., Kato, H., Takahashi, S.
J Mol Endocrinol
45
(
5
)
329
-
340
2010.11
-
Paraquat-induced oxidative stress represses phosphatidylinositol 3-kinase activities leading to impaired glucose uptake in 3T3-L1 adipocytes
Reviewed
Shibata, M., Hakuno, F., Yamanaka, D., Okajima, H., Fukushima, T., Hasegawa, T., Ogata, T., Toyoshima, Y., Chida, K., Kimura, K., Sakoda, H., Takenaka
J Biol Chem
285
(
27
)
20915
-
20925
2010.7
-
The role of insulin receptor signaling in zebrafish embryogenesis
Reviewed
Toyoshima, Y., Monson, C., Duan, C., Wu, Y., Gao, C., Yakar, S., C Sadler, K., LeRoith, D.
Endocrinology
149
(
12
)
5996
-
6005
2008.12
-
Leptin improves insulin resistance and hyperglycemia in a mouse model of type 2 diabetes
Reviewed
Toyoshima, Y., Gavrilova, O., Yakar, S., Jou, W., Pack, S., Asghar, Z., B Wheeler, M., LeRoith, D.
Endocrinology
146
(
9
)
4024
-
4035
2005.9
-
Metabolic effects of IGF-I deficiency: lessons from mouse models
Reviewed
Yakar, S., Sun, H., Zhao, H., Pennisi, P., Toyoshima, Y., Setser, J., Stannard, B., Scavo, L., LeRoith, D.
Pediatr Endocrinol Rev
3
(
1
)
11
-
19
2005.9
-
Studies involving the GH-IGF axis: Lessons from IGF-I and IGF-I receptor gene targeting mouse models
Reviewed
Yakar, S., Pennisi, P., Kim, C.H., Zhao, H., Toyoshima, Y., Gavrilova, O., LeRoith, D.
J Endocrinol Invest
28
(
5
)
19
-
22
2005.8
-
Disruption of the availability of amino acids induces a rapid reduction of serine phosphorylation of insulin receptor substrate-1 in vivo and in vitro
Reviewed
Ohne, Y., Toyoshima, Y., Kato, H.
Biosci Biotechnol Biochem
69
(
5
)
989
-
998
2005.5
-
The growth hormone-insulin like growth factor axis revisited: lessons from IGF-1 and IGF-1 receptor gene targeting
Reviewed
Yakar, S., Kim, H., Zhao, H., Toyoshima, Y., Pennisi, P., Gavrilova, O., LeRoith, D.
Pediatr Nephrol
20
(
3
)
251
-
254
2005.3
-
TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival
Reviewed
Toyoshima, Y., Karas, M., Yakar, S., Dupont, J., Helman, L., LeRoith, D.
J Biol Chem
279
(
29
)
25898
-
25904
2004.6
-
Dietary protein deprivation decreases the serine phosphorylation of insulin receptor substrate-1 in rat skeletal muscle
Reviewed
Toyoshima, Y., Ohne, Y., Takahashi, S., Noguchi, T., Kato, H.
J Mol Endocrinol
32
(
2
)
519
-
531
2004.4
-
Multiple signaling pathways are involved in the regulation of IGF-I receptor inhibition of PTEN-enhanced apoptosis
Reviewed
Wu, Y., Karas, M., Dupont, J., Zhao, H., Toyoshima, Y., Le Roith, D.
Growth Horm IGF Res
14
(
1
)
52
-
58
2004.2
-
Identification of 3,4-dihydroxy-2-oxo-butanal (L-threosone) as an intermediate compound in oxidative degradation of dehydro-L-ascorbic acid and 2,3-diketo-L-gulonic acid in a deuterium oxide phosphate buffer
Reviewed
Nishikawa, Y., Toyoshima, Y., Kurata, T.
Biosci Biotechnol Biochem
65
(
8
)
1707
-
1712
2001.8
